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Exclusion Criteria: Patients with malignant tumors or clinically ificant history of a hematological disease, or clinically ificant of tumor screening tests; Patients with a history of alcohol or drug abuse in the last 12 months; The affected limb may need an amputation in 4 weeks; Acute lower extremity arterial ischemic disease or acute progressive disease of lower extremity arterial ischemic disease; The index limb has serious infections such as cellulitis, osteomyelitis, etc. Any of the following abnormalities if the investigator judges that the abnormality may be caused by the inspection operation, still exists after one retest : TBIL exceeds 1. Please refer to this study by its ClinicalTrials.